AmpC β-lactamase induction by avibactam and relebactam
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چکیده
منابع مشابه
The β-lactamase inhibitor avibactam (NXL104) does not induce ampC β-lactamase in Enterobacter cloacae
Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...
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Background & Objective: The production of plasmid-mediated AmpC beta-lactamases (PMABLs) among urinary Klebsiella pneumoniae isolates causes a severe problem to the successful treatment of urinary tract infections (UTIs). This study was designed to evaluate antimicrobial resistance, the presence of AmpC beta-lactamase genes, and the genetic relatedness among K. pneumoniae strains separated from...
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Sir, Ceftaroline is a novel, parenteral, broad-spectrum oxyimino cephalosporin active against staphylococci, including methicillinresistant strains, and pneumococci, including penicillinand cefotaxime-resistant strains. It also has anti-Enterobacteriaceae activity, but this is constrained by lability to b-lactamases, including AmpC, extended-spectrum, KPC and metallo types. It has recently comp...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2017
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkx298